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Endothelin-1 may act as a negative inotropic agent in cardiac myocytes from young and senescent rats
A Fraticelli1, L Rossi, A I Socillo
1Laboratory of Experimental Cardiology, I.N.R.C.A., Via della Montagnola 164, Ancona, Italy.
Abstract:
The contractile response to Endothelin-1 (ET-1) has been investigated in electrically stimulated single cardiac myocytes isolated from hearts of young and senescent rats. ET-1 (0.1-10 nM) exhibited a marked negative inotropic effect in both age groups. ET-1 (1.0 nM) also reduced the occurrence of spontaneous contractile oscillations in young myocytes, suggesting depletion of sarcoplasmic reticulum-Ca(2+) stores. The possibility that ET-1 may have opposite effects on myocardial contractility is discussed.
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