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Regulation of Food Intake

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Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...

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Updated: Jul 3, 2026

Assessment of Social Transmission of Food Preferences Behaviors

Assessment of Social Transmission of Food Preferences Behaviors

Published on: January 25, 2018

Aging, modulation of food intake and spatial memory: a longitudinal study.

M Gyger¹, D Kolly, Y Guigoz

¹Nestlé Research Centre, Nestec Ltd., Vers-chez-les-Blanc, P.O. Box 44, CH-1000 Lausanne 26, Switzerland.

Archives of Gerontology and Geriatrics

|January 1, 1992

Summary

Long-term food restriction benefits spatial memory in aging rats, particularly in complex tasks. Fasting showed different effects than restriction, highlighting nuanced impacts on cognitive function.

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Area of Science:

Neuroscience
Aging Research
Nutritional Science

Background:

Long-term dietary interventions are explored for their impact on age-related cognitive decline.
Spatial memory is a critical cognitive function that often deteriorates with age.

Purpose of the Study:

To investigate the longitudinal effects of different long-term dietary regimens on spatial memory in aging rats.
To compare the efficacy of food restriction versus intermittent fasting on cognitive performance in later life.

Main Methods:

A longitudinal study involving three groups of rats: ad libitum feeding, intermittent fasting (2 days/week), and 70% calorie restriction.
Spatial memory was assessed using the Morris water maze across four age points (6, 12, 19, 24 months) through spatial learning, retrieval, and reversal tasks.

Main Results:

Dietary treatments did not affect spatial learning at any age.
At 19 and 24 months, ad libitum and fasting groups showed impaired memory retrieval, unlike the 70% restricted group.
Seventy percent calorie-restricted rats demonstrated superior adaptation in reversal learning tasks at 24 months.

Conclusions:

Calorie restriction, specifically 70% of ad libitum intake, is beneficial for maintaining spatial memory in aging rats.
Food restriction and fasting have distinct effects on spatial memory in older rats, warranting further investigation.
Dietary interventions can mitigate age-related spatial memory deficits in rodents.