Related Experiment Video
Updated: Jul 3, 2026
Use of Electromagnetic Navigational Transthoracic Needle Aspiration (E-TTNA) for Sampling of Lung Nodules
Published on: May 23, 2015
EUS-guided fine needle aspiration with and without trucut biopsy of pancreatic masses
Syed Mubashir Shah1, Afonso Ribeiro, Joe Levi
1Pancreatobiliary Interest Group at Sylvester Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33101, USA.
Context:
Endoscopic ultrasound-guided trucut biopsy (EUS TCB) has a lower yield than fine needle aspiration (FNA) in pancreatic masses but the additional use of TCB to FNA may improve the diagnostic accuracy over FNA alone.
Objective:
To compare the yield of EUS FNA alone or combined with EUS TCB for diagnosis of pancreatic masses.
Design:
Single center retrospective case control study conducted at academic tertiary center. Study conducted between March 2004 and April 2007.
Participants:
A total of 126 consecutive patients referred for EUS guided biopsy of pancreatic mass; three patients excluded from analysis, final cohort comprised 123 patients (108 malignant and 15 benign). EUS FNA was performed in 72 patients and EUS FNA+TCB was performed in 51 patients.
Main Outcome Measures:
The diagnostic performance of EUS FNA versus EUS FNA+TCB was compared.
Results:
The sensitivity, specificity and frequency of cases correctly identified for malignancy of FNA alone were 87.1% (54/62), 100% (10/10) and 88.8% (64/72), while for the combination of FNA+TCB they were: 95.7% (44/46), 100% (5/5) and 96.0% (49/51), respectively (P=0.184, 1.000, and 0.193 FNA versus FNA+TCB). No major complication occurred in either group.
Conclusion:
FNA+TCB can be safely performed in selected lesions but sensitivity is not statistically improved over FNA alone (95.7% versus 87.1%).
