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Evaluation of magnetic resonance colonography at 3.0 Tesla regarding diagnostic accuracy and image quality

Bettina Saar1, Juergen M Gschossmann, Harald M Bonel

  • 1Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, University of Bern, Bern, Switzerland. bettina.saar@insel.ch

Investigative Radiology
|July 24, 2008
PubMed
Abstract

Insights

Magnetic resonance (MR) colonography (MRC) effectively detects large colorectal lesions at 3.0 Tesla. This advanced imaging technique shows promise for diagnosing colorectal cancer and polyps.

Area of Science:

  • Radiology
  • Gastroenterology
  • Medical Imaging

Background:

  • Colorectal cancer screening relies on colonoscopy, which carries risks.
  • Magnetic resonance (MR) colonography (MRC) offers a non-invasive alternative for colorectal lesion detection.
  • Advancements in 3.0 Tesla MR systems and imaging sequences aim to improve diagnostic accuracy.

Purpose of the Study:

  • To evaluate the efficacy of 3.0 Tesla MR colonography (MRC) in detecting colorectal lesions.
  • To compare two specific T1w 3D-gradient-recalled echo (GRE) sequences with integrated parallel data acquisition (iPAT) for MRC.
  • To assess the diagnostic performance of MRC against conventional colonoscopy.

Main Methods:

  • Prospective study of 34 symptomatic patients undergoing dark lumen MRC at 3.0 Tesla before conventional colonoscopy (CC).
  • Two high-resolution T1w 3D-GRE sequences (3D-FLASH with iPAT 2 and 3D-VIBE with iPAT 3) were acquired.
  • Image quality was assessed qualitatively and quantitatively, with CC serving as the reference standard.

Main Results:

  • MRC accurately identified all large polyps (>5 mm) and all carcinomas (100% detection rate).
  • Fifty percent of small polyps (
  • Excellent diagnostic quality was achieved in over 90% of colonic segments for both sequences, with 3D-FLASH showing improved signal-to-noise ratio after contrast enhancement.

Conclusions:

  • 3.0 Tesla MR colonography using 3D-GRE sequences and iPAT is a feasible technique for colorectal lesion detection.
  • The 3D-FLASH sequence demonstrated slightly better image quality compared to 3D-VIBE, though both showed comparable diagnostic performance.
  • MRC shows significant potential as a non-invasive tool for colorectal cancer screening and diagnosis.

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