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Tumour-targeted nanomedicines: principles and practice
T Lammers1, W E Hennink, G Storm
1Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, Utrecht 3584 CA, The Netherlands.
British Journal of Cancer
|July 24, 2008
Summary
Nanomedicines improve drug delivery for cancer treatment. These nanometre-sized carriers enhance the therapeutic index of anticancer agents by targeting tumours, showing significant potential for improved patient outcomes.
Area of Science:
- Nanomedicine
- Drug Delivery Systems
- Oncology
Background:
- Drug targeting systems utilize nanometre-sized carriers to improve the biodistribution of systemically administered therapeutics.
- Nanomedicines offer a strategy to enhance the therapeutic index of anticancer agents.
Purpose of the Study:
- To summarize key tumor-targeting nanomedicine systems and strategies.
- To discuss recent advancements and future prospects in the field of tumor-targeted nanomedicines.
Main Methods:
- Review and synthesis of existing literature on nanomedicine targeting systems.
- Analysis of evaluated tumor-targeted nanomedicines and their impact on therapeutic index.
Main Results:
- Evidence supports substantial improvement in the therapeutic index of anticancer drugs using nanomedicine approaches.
- Various nanomedicine systems and strategies have been developed and evaluated for tumor targeting.
Conclusions:
- Nanomedicines represent a significant advancement in cancer therapy by improving drug delivery and efficacy.
- Continued development in tumor-targeted nanomedicines holds promise for future cancer treatment strategies.
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