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Dissection of Human Retina and RPE-Choroid for Proteomic Analysis
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NEIBank: genomics and bioinformatics resources for vision research
Graeme Wistow1, Katherine Peterson, James Gao
1Section on Molecular Structure and Functional Genomics, National Eye Institute, National Institutes of Health, Bethesda, MD 20892-0703, USA. graeme@helix.nih.gov
Molecular Vision
|July 24, 2008
Summary
NEIBank offers integrated genomics and bioinformatics data for vision research, including gene expression and eye disease information. This resource aids understanding of eye tissue transcription and pathology.
Area of Science:
- Genomics and Bioinformatics in Vision Research
Background:
- Vision research requires integrated data on gene expression and ocular diseases.
- Existing resources may lack comprehensive, eye-specific genomic and transcriptomic information.
Purpose of the Study:
- To present NEIBank, an integrated resource for vision research genomics and bioinformatics.
- To consolidate expressed sequence tag (EST) data, cDNA clones, SAGE data, and disease gene information for ocular tissues.
Main Methods:
- Integrated expressed sequence tag (EST) data and sequence-verified cDNA clones from various species' eye tissues.
- Provided web-based access to human eye-specific Serial Analysis of Gene Expression (SAGE) data via EyeSAGE.
- Developed comprehensive, annotated databases for human eye disease genes and candidate loci.
- Integrated all data into EyeBrowse, an eye-centric genome browser.
Main Results:
- NEIBank provides a unified platform for accessing diverse vision research data.
- EyeSAGE offers specific insights into human ocular gene expression.
- Databases facilitate the study of genetic factors in eye diseases.
- EyeBrowse enables integrated visualization of expression and disease data.
Conclusions:
- NEIBank serves as a comprehensive resource for understanding eye tissue transcriptional repertoires.
- The integrated data and tools in NEIBank advance research into the molecular basis of eye diseases.
- This resource enhances the study of ocular pathology through genomics and bioinformatics.
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