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Assessment of thoracic aortic conformational changes by four-dimensional computed tomography angiography in patients
Tim F Weber1, Maria-Katharina Ganten, Dittmar Böckler
1Department of Radiology, German Cancer Research Center, Heidelberg, Germany. t.weber@dkfz.de
Insights
Heartbeat-related aortic distension in chronic aortic dissection type B (CADB) shows greater changes in the true lumen. Non-dissected segments exhibit even distension, while the dissected aorta
Area of Science:
- Cardiovascular Imaging
- Thoracic Aorta
- Aortic Dissection
Background:
- Chronic aortic dissection type B (CADB) affects the thoracic aorta.
- Understanding aortic distension in CADB is crucial for patient management.
Purpose of the Study:
- To characterize heartbeat-related distension in dissected and non-dissected thoracic aortic segments in CADB patients.
- To compare distension amplitudes between different aortic segments and channels.
Main Methods:
- ECG-gated computed tomography angiography in ten CADB patients.
- Multiplanar reformations at 20 time points of the R-R interval.
- Quantification of relative amplitudes of aortic area and major/minor axis diameter changes.
Main Results:
- Aortic area and minor axis diameter showed significantly greater distension in the true channel (Ct) compared to the false channel (Cf) and aortic vertex (B).
- No significant differences were observed in major axis diameter distension.
- Non-dissected aortic arch segments (A, B) demonstrated evenly distributed distension.
Conclusions:
- Heartbeat-related distension is evenly distributed in non-dissected aortic arch segments in CADB.
- The true channel of the dissected aorta experiences significantly greater conformational changes due to altered blood flow properties.
Abstract:
To characterize the heartbeat-related distension of dissected and non-dissected thoracic aortic segments in chronic aortic dissection type b (CADB) ECG-gated computed tomography angiography was performed in ten CADB patients. For 20 time points of the R-R interval, multiplanar reformations were taken at non-dissected (A, B) and dissected (C) aorta: ascending aorta (A), aortic vertex (B), 10 cm distal to left subclavian (Ct, true channel; Cf, false channel). Relative amplitudes of aortic area and major and minor axis diameter changes were quantified. Area amplitudes were 12.9 +/- 3.7%, 11.4 +/- 1.8%, 16.5 +/- 5.9% and 10.5 +/- 5.7% at A, B, Ct and Cf, respectively. Area amplitudes were significantly greater at Ct than at Cf and B (p < 0.05). Major axis diameter amplitudes were 7.7 +/- 1.9%, 6.2 +/- 1.3%, 5.9 +/- 2.0% and 6.1 +/- 3.6% at A, B, Ct and Cf, respectively. There were no differences in major axis diameter amplitudes. Minor axis diameter amplitudes were 6.7 +/- 2.1%, 8.4 +/- 1.9%, 12.7 +/- 6.3% and 6.0 +/- 2.2% at A, B, Ct and Cf, respectively. Minor axis diameter amplitudes were significantly the greatest at Ct (p < 0.05). In CADB, the heartbeat-related distension of aortic area and diameter is evenly distributed over the non-dissected aortic arch. As a result from different blood flow properties, there are significantly greater conformational changes in the true channel of the dissected aorta.
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