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Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients
1Pomeranian Medical University, Szczecin, Poland.
Background:
Ten patients with breast cancer and a breast cancer susceptibility gene 1 (BRCA1) mutation, who presented with stages I to III breast cancer between December 2006 and 2007, were treated with four cycles of neoadjuvant cisplatin, followed by mastectomy and conventional chemotherapy.
Methods:
The excised breast tissue and lymph nodes were examined for the presence of residual disease.
Results:
Pathologic complete response was observed in nine patients (90%).
Conclusions:
Platinum-based chemotherapy appears to be effective in a high proportion of patients with BRCA1-associated breast cancers. Clinical trials are now warranted to determine the optimum treatment for this subgroup of breast cancer patients.
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