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Effect of storage conditions on compaction behavior of two grades of spray-dried lactose
Faraj Atassi1, Ahmad Almaya, Aktham Aburub
1Eli Lilly & Company, Pharmaceutical Sciences Research and Development, Lilly Research Laboratories, Indianapolis, Indiana 46285, USA.
Abstract:
In this work we examine the effect of storage conditions (moisture exposure) on the compression behavior of 2 grades of spray-dried lactose (Pharmatose DCL 11 and Pharmatose DCL 14) under 2 different circumstances. The first was to expose powder samples to moisture, then compress them. The second was to expose precompressed tablets to moisture. We clearly show that the effect of moisture exposure and amorphous content crystallization in spray-dried lactoses on compaction behavior depends on whether this moisture exposure takes place before or after compression. In addition, the impact of storage conditions depends on the grade of spray-dried lactose.
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