Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From Bench to Bedside: Stem and Progenitor Cell-Derived Extracellular Vesicles in Cardiac Therapy.

Stem cells (Dayton, Ohio)·2026
Same author

Sex-specific cardiac ageing and sympathetic compensation: a translational study.

European heart journal·2025
Same author

Minimally invasive aspiration of thrombi and masses in left-sided cardiac chambers: a comprehensive literature review.

Frontiers in cardiovascular medicine·2025
Same author

Aorto-Right Atrial Fistula Complicating Transseptal Puncture: Integrating Contemporary Imaging and the Structuralist's Toolbox.

JACC. Case reports·2025
Same author

External Validation of the REACT-HF Score for Predicting Heart Failure in Patients With Atrial Fibrillation.

Journal of the American Heart Association·2025
Same author

Comparative safety and efficacy of new-generation single-layer polytetrafluorethylene- versus polyurethane-covered stents in patients with coronary artery perforation for the RECOVER (REsults after percutaneous interventions with COVERed stents) Investigators.

Cardiovascular intervention and therapeutics·2025
Same journal

Revue medicale suisse·2026
Same journal

Revue medicale suisse·2026
Same journal

Revue medicale suisse·2026
Same journal

Revue medicale suisse·2026
Same journal

Revue medicale suisse·2026
Same journal

[Erythema multiforme : target deciphering].

Revue medicale suisse·2026
See all related articles

Related Experiment Video

Updated: Jul 3, 2026

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans
08:21

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans

Published on: July 21, 2023

[Microvascular dysfunction and myocardial ischemia].

Giuseppe Vassalli1, Eric Eeckhout, Pierre Vogt

  • 1Division de cardiologie, Service de cardiologie et Pôle cardiovasculaire et métabolique, CHUV, Lausanne. giuseppe.vassalli@chuv.ch

Revue Medicale Suisse
|July 25, 2008
PubMed
Summary
This summary is machine-generated.

Assessing myocardial microvascular function is crucial for understanding heart ischemia, especially when coronary arteries appear normal. It helps evaluate reperfusion after heart attacks and diagnose conditions like hypertension and cardiomyopathy.

More Related Videos

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
08:35

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

Related Experiment Videos

Last Updated: Jul 3, 2026

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans
08:21

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans

Published on: July 21, 2023

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
08:35

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

Area of Science:

  • Cardiology
  • Vascular Biology
  • Myocardial Ischemia Research

Context:

  • Intramural arteriolar lesions impact myocardial ischemic threshold.
  • Microvascular dysfunction is characterized by reduced coronary blood flow during maximal hyperemia with normal coronary arteries.
  • This dysfunction can indicate endothelial dysfunction in diabetes and hyperlipidemia, or structural/functional changes in hypertrophic cardiomyopathy, aortic stenosis, and hypertension.

Purpose:

  • To highlight the significance of assessing microvascular function in various cardiac conditions.
  • To emphasize its role in evaluating myocardial reperfusion post-acute myocardial infarction.
  • To underscore its importance in diagnosing myocardial ischemia without significant coronary artery stenoses.

Summary:

  • Functional or structural issues in intramural arterioles affect the heart's tolerance to ischemia.
  • Microvascular dysfunction, seen as decreased coronary blood flow, is linked to conditions like diabetes, hypertension, and hypertrophic cardiomyopathy.
  • Evaluating microvascular function is key for assessing reperfusion after heart attacks and diagnosing ischemia in non-obstructive coronary artery disease.

Impact:

  • Improves diagnostic accuracy for myocardial ischemia.
  • Enhances the assessment of treatment effectiveness in acute myocardial infarction.
  • Provides critical insights into the pathophysiology of heart disease in diverse patient populations.