Antagonic-stress: A therapeutic composition for deceleration of aging. II. Brain lipofuscinolytic activity...

Electron microscopic morphology and distribution of brain lipofuscin and ceroid (LP) were studied after 8 weeks of daily treatment with Antagonic-Stress (AS), a new combination of various components with cerebroprotective and anti-aging properties. LP characteristics were investigated in selected brain areas of control adult (CA), control old (CO) and treated old (TO) groups of 30 male Wistar rats. Cellular and regional distributions of LP in the TO group were very different from those of the CO group and resembled that of the CA group. In addition, electron microscopic signs of dissolution of LP were constantly observed in the TO group. Neurons and glia cells of TO group displayed an intense replacement of damaged organelles, especially of mitochondria, with normal organelles, many of them in hyperfunctional stages. Neuronal, glial and capillary LP lysis occurred simultaneously with neuro-glial LP transfer and capillary LP elimination. Numerous microglia cells overloaded with processed LP were identified in the vicinity of the capillary areas. AS treatment of 8 weeks induces lysis of LP which may be useful for therapeutic purposes in various brain pathologies and in deceleration of brain aging in healthy elderly.