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Updated: Jul 3, 2026
Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
Published on: June 8, 2019
Evaluation of tumor microsatellite instability in laryngeal cancer using five quasimonomorphic mononucleotide repeats
M Rózańska-Kudelska1, I Walenczak, W Pepiński
1Departament of Otolaryngology, Medical University of Bialystok, Poland.
Purpose:
To determine microsatellite instability (MSI) in squamous cell carcinoma of the larynx.
Material And Methods:
The study was performed in a group of 30 male patients, aged 42-47 years. All patients underwent total laryngectomy with lymph nodectomy. Histologically all tumors were squamous cell carcinomas. Detection of MSI was based on comparison of allelic profiles generated from amplification of matching normal and tumor DNA.
Results:
The appearance of novel alleles in the tumor DNA indicated microsatellite instability. MSI analysis showed a microsatellite stable phenotype in 23 cases (77%).
Conclusions:
MSI may not contribute to the development of squamous cell carcinoma of the larynx.
