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Related Concept Videos

Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview

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Related Experiment Video

Updated: Jul 3, 2026

Generation of Natural Killer Cells from Human Expanded Potential Stem Cells
06:53

Generation of Natural Killer Cells from Human Expanded Potential Stem Cells

Published on: January 13, 2023

Human natural killer cells.

Michael A Caligiuri1

  • 1The Ohio State University Comprehensive Cancer Center, The James Cancer Hospital & Solove Research Institute, 300 West 10th St, Rm 517, Columbus, OH 43210, USA. michael.caligiuri@osumc.edu

Blood
|July 25, 2008
PubMed
Summary
This summary is machine-generated.

Natural killer (NK) cells, part of the innate immune system, are crucial for immune surveillance. Recent advances in understanding NK cell receptors have led to breakthroughs in treating human cancers.

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Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells
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Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells

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Last Updated: Jul 3, 2026

Generation of Natural Killer Cells from Human Expanded Potential Stem Cells
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Generation of Natural Killer Cells from Human Expanded Potential Stem Cells

Published on: January 13, 2023

Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells
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Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells

Published on: February 22, 2020

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Natural killer (NK) cells are large granular lymphocytes within the innate immune system.
  • Unlike adaptive immune cells (T and B lymphocytes), NK cells lack gene rearrangement for antigen specificity.
  • Their function in immune surveillance has been a subject of extensive research.

Purpose of the Study:

  • To summarize the current understanding of NK cell function and receptor biology.
  • To highlight the translational impact of NK cell research in oncology.

Main Methods:

  • Review of existing literature on NK cell biology and receptor function.
  • Analysis of recent discoveries in NK cell immunology.

Main Results:

  • Significant progress has been made in understanding how NK cells recognize targets.
  • NK cell receptor biology has provided crucial insights into immune surveillance mechanisms.

Conclusions:

  • Advances in NK cell research have direct applications in cancer treatment.
  • NK cells represent a promising area for developing novel anti-malignancy therapies.