Related Experiment Video
Updated: Jul 3, 2026

Collection of Skeletal Muscle Biopsies from the Superior Compartment of Human Musculus Tibialis Anterior for Mechanical Evaluation
Published on: September 27, 2020
Histological changes of the skeletal muscle due to muscle tension: a study in rats
P Devkota1, Bing-fan Zeng, Jian-fei Tang
1Department of Orthopaedic Surgery, Patan Hospital, Lalitpur, Lagankhel, Lalitpur, Nepal.
Objective:
To analyze the influence of muscle tension in the histological changes of the skeletal muscle.
Methods:
Fifty-four Sprague-Dawley (SD) rats were randomly divided into 3 groups. The left gastrocnemius muscles of the rats were dissected with only the neurovascular pedicles intact; the tibial nerves were cut and immediately repaired by epineurial suture. Then the Achilles tendons were isolated and treated accordingly; the Achilles tendon were lengthened by 0.5 cm in lengthened group, shortened by 0.5 cm in shortened group and left alone in normal (control) group. In the 2nd, 4th and 8th weeks after operation, the specimens were taken from gastrocnemius muscle for histological study by light and electron microscope.
Results:
In comparison between the groups, the gastrocnemius muscles in the shortened group showed less severe muscle atrophy and connective tissue proliferation, bigger diameter and cross section area of the muscle fibre than those in the normal and lengthened groups in all the postoperative periods.
Conclusion:
A proper high tension of the muscle may decrease the muscle dystrophy and stops the histological changes of skeletal muscle by having much longer fibre length and bigger cross sectional area. Also increases the muscle function as the muscle active force-generating range is determined by muscle fibre length, while maximum muscle force is determined by physiologic cross-sectional area.
Related Concept Videos
Alterations in Muscle Tone lll
Alterations in Muscle Tone ll
Relaxation of Skeletal Muscles
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open.
Overview of Skeletal Muscle
Skeletal Muscle Anatomy
Isotonic and Isometric Muscle Contractions
Isotonic contractions
Isotonic contractions occur when a muscle changes length while the...

