Jove
Visualize
Contact Us

Related Experiment Videos

Coexisting hyperparathyroidism with thyrotoxicosis.

D M McGowan1, A Vaswani, I Shperling

  • 1Winthrop University Hospital, Division of Endocrinology, Mineola, Long Island, New York 11501.

Journal of Endocrinological Investigation
|April 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[News in osteogenesis imperfecta: from research to clinical management].

Revue medicale suisse·2015
Same author

Who is responsible for the efficacy and safety of pet foods?

The Canadian veterinary journal = La revue veterinaire canadienne·2009
Same author

An immunohistochemical study of the secretory immune system in human fetal endocrine glands and their precursors.

Early pregnancy·2001
Same author

Differences in skeletal and muscle mass with aging in black and white women.

American journal of physiology. Endocrinology and metabolism·2000
Same author

Total-body calcium estimated by delayed gamma neutron activation analysis and dual-energy X-ray absorptiometry.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2000
Same author

Body composition by dual-energy X-ray absorptiometry in black compared with white women.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·1999
Same journal

Association of C-reactive protein to albumin ratio with progression of CKD and all-cause mortality in diabetic CKD.

Journal of endocrinological investigation·2026
Same journal

PMOS in black girls and women: from high to low risk.

Journal of endocrinological investigation·2026
Same journal

Inhibition of TGF-β1/Smad signaling reverses the dedifferentiated phenotype of thyroid cancer cells in three-dimensional culture.

Journal of endocrinological investigation·2026
Same journal

lncRNA PANDAR predicts adverse pregnancy outcomes and reflects hyperglycemia-associated cellular stress in gestational diabetes mellitus.

Journal of endocrinological investigation·2026
Same journal

Correction: Early in, early out: reproductive lifespan timing and cardiometabolic risk in women.

Journal of endocrinological investigation·2026
Same journal

Adult mice are more susceptible to high-fat diet-induced visceral adiposity and insulin resistance than juvenile mice.

Journal of endocrinological investigation·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

The rare coexistence of hyperparathyroidism and thyrotoxicosis requires careful diagnosis. Measuring parathyroid hormone (PTH) levels after thyroid normalization is key to confirming hyperparathyroidism.

Area of Science:

  • Endocrinology
  • Internal Medicine
  • Medical Case Reports

Background:

  • The simultaneous occurrence of hyperparathyroidism and thyrotoxicosis is exceptionally uncommon.
  • Distinguishing between these conditions can be challenging due to overlapping clinical and biochemical features.
  • Thyrotoxicosis typically suppresses parathyroid hormone (PTH) levels, making elevated PTH a potential indicator of concurrent hyperparathyroidism.

Observation:

  • A patient presented with thyrotoxicosis and asymptomatic hypercalcemia, alongside markedly elevated serum immunoreactive parathyroid hormone (iPTH) levels.
  • Treatment for thyrotoxicosis with propylthiouracil and propranolol normalized serum calcium and significantly reduced iPTH levels.
  • Upon tapering medication and achieving a euthyroid state, hypercalcemia recurred, accompanied by rising iPTH levels.

Related Experiment Videos

Findings:

  • Serum PTH levels are crucial for diagnosing coexisting hyperparathyroidism in patients with thyrotoxicosis.
  • In this case, iPTH levels decreased with thyrotoxicosis treatment but rose again with recurrence, supporting a dual diagnosis.
  • The study highlights that persistently elevated serum calcium and iPTH levels after achieving a euthyroid state are necessary for a definitive diagnosis of hyperparathyroidism.

Implications:

  • The findings support the recommendation for assessing PTH levels in patients suspected of having both hyperparathyroidism and hyperthyroidism.
  • A definitive diagnosis of hyperparathyroidism should only be made after the patient is rendered euthyroid, with persistent hypercalcemia and elevated iPTH.
  • While other markers like vitamin D and serum phosphate are less reliable, iPTH determination is a consistently helpful initial diagnostic test.