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Toxicity Testing in Animals

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

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Related Experiment Video

Updated: Jul 3, 2026

A Ferret Model of Inflammation-sensitized Late Preterm Hypoxic-ischemic Brain Injury

A Ferret Model of Inflammation-sensitized Late Preterm Hypoxic-ischemic Brain Injury

Published on: November 19, 2019

Death as a study endpoint: why use ferrets?

Stephen B Harvey¹, Leanne C Alworth, S Mark Tompkins

¹Department of Population Health, University Research Animal Resources, Athens, GA, USA.

|July 25, 2008

Summary

No abstract available in PubMed .

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