Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Burn Injuries

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...

Inflammatory Response

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

Inflammation: Introduction

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...

Acute Inflammation III: Local and Systemic Effects

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...

Diabetic Neuropathy

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...

Chronic Pancreatitis II: Pathophysiology

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Why research on Endocrine Disrupting Chemicals is still worthwhile. Editorial.

Annali dell'Istituto superiore di sanita·2017

Same author

Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects.

eLife·2017

Same author

Intraperitoneal adoptive transfer of mesenchymal stem cells enhances recovery from acid aspiration acute lung injury in mice.

Intensive care medicine experimental·2017

Same author

Driver mutations (JAK2V617F, MPLW515L/K or CALR), pentraxin-3 and C-reactive protein in essential thrombocythemia and polycythemia vera.

Journal of hematology & oncology·2017

Same author

Analysis of Food Safety and Security Challenges in Emerging African Food Producing Areas through a One Health Lens: The Dairy Chains in Mali.

Journal of food protection·2017

Same author

The Hotspot for (Global) One Health in Primary Food Production: Aflatoxin M1 in Dairy Products.

Frontiers in public health·2017

Search research articles

Related Experiment Video

Updated: Jun 29, 2026

Rapid Determination of the Thermal Nociceptive Threshold in Diabetic Rats

Rapid Determination of the Thermal Nociceptive Threshold in Diabetic Rats

Published on: May 17, 2012

Cancer-related inflammation.

Alberto Mantovani¹, Paola Allavena, Antonio Sica

¹Istituto Clinico Humanitas IRCCS, Via Manzoni 56, Rozzano, 20089 Milan, Italy. alberto.mantovani@humanitas.it

|July 25, 2008

Summary

Inflammation within the tumor microenvironment fuels cancer growth, promoting cell survival, spread, and resistance to treatment. Understanding these inflammatory pathways offers new targets for cancer diagnosis and therapy.

Area of Science:

Oncology
Immunology
Cancer Biology

Background:

Inflammation is a key component of the tumor microenvironment.
Inflammatory conditions can precede or be induced by cancer development.
Chronic inflammation within tumors promotes cancer progression.

Purpose of the Study:

To explore the role of inflammation in cancer.
To identify the mechanisms by which inflammation promotes tumors.
To discover new molecular targets for cancer treatment.

Main Methods:

Review of existing literature on cancer-related inflammation.
Analysis of molecular pathways involved in tumor-promoting inflammation.
Identification of potential therapeutic targets.

More Related Videos

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment

Published on: November 6, 2018

Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection

Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection

Published on: August 23, 2022

Related Experiment Videos

Last Updated: Jun 29, 2026

Rapid Determination of the Thermal Nociceptive Threshold in Diabetic Rats

Rapid Determination of the Thermal Nociceptive Threshold in Diabetic Rats

Published on: May 17, 2012

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment

Published on: November 6, 2018

Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection

Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection

Published on: August 23, 2022

Main Results:

Inflammation aids malignant cell proliferation, survival, angiogenesis, and metastasis.
It also subverts immune responses and affects treatment efficacy.
Molecular pathways driving cancer inflammation are being elucidated.

Conclusions:

Tumor-associated inflammation has significant pro-tumorigenic effects.
Unraveling these pathways reveals novel targets for improved cancer diagnosis and therapy.