Related Experiment Video
Updated: Jul 3, 2026

In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy
Published on: July 29, 2019
Models of the pulsatile hydrodynamics of cerebrospinal fluid flow in the normal and abnormal intracranial system
S Cheng1, E Jacobson, L E Bilston
1Prince of Wales Medical Research Institute, University of New South Wales, Randwick, Australia. enquiries_cheng@hotmail.com
Abstract:
Images obtained from magnetic resonance imaging have helped to ascertain that both the cerebrospinal fluid (CSF) and brain move in a pulsatile manner within the cranium. However, these images are not able to reveal any quantitative information on the physiological forces that are associated with pulsatile motion. Understanding both the pressure and velocity flow field of CSF in the ventricles is important to help understand the mechanics of hydrocephalus. Four separate fluid structure interaction models of the ventricular system in the sagittal plane were created for this purpose. The first model was of a normal brain. The second and third models were pathological brain models with aqueductal stenosis at various locations along the fluid pathway. The fourth model was of a hydrocephalic brain. Results revealed the hydrodynamics of CSF pulsatile flow in the ventricles of these models. Most importantly, it has also revealed the different changes in CSF pulsatile hydrodynamics caused by the various locations of fluid flow obstructions.
More Related Videos
Related Concept Videos
Increased Intracranial Pressure ll: Pathophysiology
Increased Intracranial Pressure l: Introduction
Cerebrospinal Fluid
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain.
Cerebral Edema ll: Pathophysiology
Cerebral Edema l: Introduction
Anatomy of the Brain: Ventricles

