Related Experiment Video
Updated: Jul 3, 2026
09:51
Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
Published on: March 3, 2020
Collisional solute release from thermally activated lipid particles
Pengyun Zeng1, Jeffrey Mahlberg, Timothy Scott Wiedmann
1Department of Pharmaceutics, University of Minnesota, Minneapolis, MN 55455, USA.
Drug Development and Industrial Pharmacy
|July 25, 2008
Summary
Solid lipid particles demonstrate potential as thermo-activated drug delivery systems. Drug release from these particles requires both micelles and heat, with release rates influenced by particle and micelle concentrations.
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Physical Chemistry
Background:
- Solid lipid particles (SLPs) are investigated for controlled drug delivery applications.
- Thermo-activated systems offer potential for targeted and on-demand drug release.
- Understanding release kinetics is crucial for optimizing drug delivery efficacy.
Purpose of the Study:
- To evaluate submicron-sized diphenylhexatriene (DPH)/myristyl alcohol solid lipid particles as a thermo-activated drug delivery system.
- To investigate the influence of micelle concentration and thermal activation on DPH release rates.
- To elucidate the mechanisms governing drug release from SLPs.
Main Methods:
- Submicron-sized DPH/myristyl alcohol particles were fabricated using an atomization/drying process.
- Drug release kinetics were measured by monitoring DPH release into sodium dodecyl sulfate (SDS) micellar solutions under varying conditions.
- A design study was employed to analyze the relationships between release rate, particle concentration, and micelle concentration.
Main Results:
- The release of DPH from SLPs was found to be dependent on both the presence of micelles and thermal activation.
- Initial DPH release rates were generally linear but showed nonlinearity at low micelle concentrations (rate decrease) and high particle/micelle concentrations (rate increase).
- Release rate was linearly proportional to particle concentration and nonlinearly related to micelle concentration, suggesting a saturable, possibly collision-based, release mechanism.
Conclusions:
- Solid lipid particles can function as thermo-activated drug delivery systems.
- Micelles and thermal energy are essential for DPH release, with release kinetics modulated by concentration-dependent factors.
- The findings suggest a saturable, collision-based mechanism for DPH release, providing insights for future drug delivery system design.
More Related Videos
10:58SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy
Published on: August 24, 2016
13:30Mass-Sensitive Particle Tracking to Characterize Membrane-Associated Macromolecule Dynamics
Published on: February 18, 2022
Related Concept Videos
01:29The Colloidal State
The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called the...
02:35Energetics of Solution Formation
The formation of a solution is an example of a spontaneous process, which is a process that occurs under specified conditions without energy from some external source.
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Formation of the solution requires the solute–solute and solvent–solvent electrostatic forces to...
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Formation of the solution requires the solute–solute and solvent–solvent electrostatic forces to...
02:05Entropy and Solvation
The process of surrounding a solute with solvent is called solvation. It involves evenly distributing the solute within the solvent. The rule of thumb for determining a solvent for a given compound is that like dissolves like. A good solvent has molecular characteristics similar to those of the compound to be dissolved. For example, polar solutions dissolve polar solutes, and apolar solvents dissolve apolar solutes. A polar solvent is a solvent that has a high dielectric constant (ϵ ≥ 15); an...
03:00Solubility
Solution, Solubility, and Solubility Equilibrium
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules, atoms, and/or ions)...
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules, atoms, and/or ions)...
02:16Solution Formation
There is no one solvent that can dissolve every type of solute. Some substances that readily dissolve in a certain solvent might be insoluble in a different solvent. A simple way to predict which substances dissolve in which solvent is the phrase "like dissolves like". This means that polar substances, such as salt and sugar, dissolve in a polar substance like water. In contrast, non-polar substances are more soluble in non-polar solvents such as carbon tetrachloride.
This selective solubility...
This selective solubility...
01:09Solubility Equilibria: Overview
When a substance such as sodium chloride is added to water, it dissolves, forming an aqueous solution. The extent of dissolution is called solubility. The process of dissolution can exist in equilibrium, just like other chemical processes. Solubility equilibria are also called precipitation equilibria because the process of solubility can be reversible. The reverse of the solubility process is called precipitation.
Solubility is important in biological and environmental processes. A notable...
Solubility is important in biological and environmental processes. A notable...