Does permanent cardiac stimulation through atrial natriuretic peptide secretion influence the basic parameters of...

Area of Science:

• Cardiology
• Nephrology
• Endocrinology

Background:

• Atrioventricular (AV) conduction disturbances necessitate pacemaker implantation.
• Evaluating the impact of VVI and DDD pacemakers on atrial humoral function and renal function is crucial.

Purpose of the Study:

• To assess changes in atrial natriuretic peptide (ANP) concentration post-pacemaker implantation.
• To evaluate alterations in renal function parameters following pacemaker implantation.
• To determine correlations between ANP levels and renal function.

Main Methods:

• Study included patients with second- and third-degree AV block receiving VVI or DDD/VDD pacemakers.
• Plasma ANP levels were measured using radioimmunoassay.
• Renal function parameters, including creatinine clearance and concentration, were analyzed.

Main Results:

• Significant decrease in plasma ANP observed in both VVI and DDD/VDD pacemaker groups post-implantation.
• Creatinine clearance significantly increased in both groups at 30 days post-implantation.
• Plasma creatinine concentration significantly decreased in both groups at 30 days post-implantation.
• A positive correlation was found between creatinine clearance and plasma ANP concentration.

Conclusions:

• Pacemaker implantation in patients with AV disturbances leads to reduced blood ANP concentrations.
• Renal function shows improvement after pacemaker implantation.
• Pacemakers may positively influence atrial humoral and renal function.