Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...

Chronic Kidney Disease IV: Nursing Management

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...

Factors Affecting Renal Clearance: Renal Impairment

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Prominent Pro-Inflammatory Phenotype Is Observed in Replication and Stress-Induced Senescent Mast Cells.

Aging cell·2025

Same author

The Impact of Frailty Status on Pulmonary Function and Mortality in Older Patients with Chronic Obstructive Pulmonary Disease.

The journal of nutrition, health & aging·2023

Same author

Issues in Medicine.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2023

Same author

Verbal working memory encodes phonological and semantic information differently.

Cognition·2022

Same author

Effects of Aerobic Exercise Training on Daily Psychological Processes in Family Caregivers: Secondary Analyses of a Randomized Controlled Trial.

Affective science·2022

Same author

COVID-19 vaccination and breakthrough infections in patients with cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2021

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Physical functioning in patients with chronic kidney disease.

J Padilla¹, J Krasnoff, M Da Silva

¹Department of Kinesiology, Indiana University, Bloomington, Indiana, USA.

Journal of Nephrology

|July 25, 2008

Summary

Patients with chronic kidney disease (CKD) have significantly reduced physical functioning before starting dialysis. Interventions are needed to improve physical function in CKD patients prior to renal replacement therapy (RRT).

More Related Videos

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Related Experiment Videos

Last Updated: Jul 3, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Area of Science:

Nephrology
Exercise Physiology
Gerontology

Background:

Patients undergoing dialysis for chronic kidney disease (CKD) exhibit diminished physical functioning.
Limited data exists on the physical functioning status of CKD patients before initiating renal replacement therapy (RRT).

Purpose of the Study:

To assess the physical functioning of pre-dialysis CKD patients using objective and subjective measures.
To investigate the relationship between physical functioning parameters and renal function in this cohort.

Main Methods:

Thirty-two pre-dialysis CKD patients underwent a symptom-limited treadmill test for peak oxygen uptake (VO2peak).
Physical performance was evaluated through gait speed, sit-to-stand tests, and the 6-minute walk test.
Self-reported physical functioning was assessed using the SF-36 questionnaire.

Main Results:

Pre-dialysis CKD patients demonstrated reduced VO2peak, physical performance, and self-reported functioning compared to age-predicted norms.
VO2peak correlated significantly with all assessed physical functioning measures.
Maximal gait speed and the physical composite scale (PCS) showed significant correlations with estimated glomerular filtration rate (eGFR).

Conclusions:

Pre-dialysis CKD patients exhibit objectively and subjectively impaired physical functioning.
Low physical functioning is a predictor of outcomes in dialysis patients, underscoring the need for interventions.
Maintaining or enhancing physical function before RRT initiation is crucial for CKD patient management.