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Related Concept Videos

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Neurotransmitters01:31

Neurotransmitters

Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
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Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
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Related Experiment Video

Updated: Jul 3, 2026

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome
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Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Published on: September 23, 2015

What do we know about serotonin?

Catherine Jonnakuty1, Claudia Gragnoli

  • 1Laboratory of Molecular Genetics of Complex and Monogenic Disorders, Department of Medicine and Cellular & Molecular Physiology, M. S. Hershey Medical Center, Hershey, Pennsylvania, USA.

Journal of Cellular Physiology
|July 25, 2008
PubMed
Summary

This review details serotonin physiology, exploring its role in cardiovascular, gastrointestinal, and circulatory systems. It also touches upon emerging functions in bone and glucose metabolism, and genetic links to mood disorders.

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A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices
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Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome
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A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices
07:56

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices

Published on: August 11, 2021

Area of Science:

  • Physiology
  • Biochemistry
  • Genetics

Background:

  • Serotonin, a key neurotransmitter, plays a crucial role in various physiological processes.
  • Understanding serotonin's peripheral functions is essential for comprehending human health.
  • Existing research provides a foundation for exploring serotonin's broader physiological impact.

Purpose of the Study:

  • To review fundamental human serotonin physiology, including its biochemistry and metabolism.
  • To summarize established roles in cardiovascular, gastrointestinal, and circulatory systems.
  • To highlight emerging roles in bone and glucose metabolism and genetic associations with mood disorders.

Main Methods:

  • Literature review of existing studies on serotonin physiology.
  • Analysis of biochemical and metabolic pathways of serotonin.
  • Summary of findings from genetic studies on serotonin and its transporter genes.

Main Results:

  • Serotonin is integral to cardiovascular, gastrointestinal, and circulatory functions.
  • Emerging evidence suggests roles in bone pathways and glucose uptake.
  • Genetic studies link serotonin and serotonin transporter genes to mood and behavioral disorders.

Conclusions:

  • Serotonin possesses well-defined peripheral physiological roles.
  • Further research into novel areas like bone and glucose metabolism is warranted.
  • Genetic variations in serotonin pathways are significant in understanding mood disorders.