Related Experiment Video

Updated: Jul 3, 2026

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt
12:27

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt

Published on: May 7, 2015

Transplant-associated Ochroconis gallopava infections

S Shoham1, L Pic-Aluas, J Taylor

  • 1Section of Infectious Diseases, Washington Hospital Center, Washington, District of Columbia 20010, USA. Shmuel.Shoham@medstar.net

Transplant Infectious Disease : an Official Journal of the Transplantation Society
|July 25, 2008
PubMed
Abstract

Insights

Ochroconis gallopava infections in solid organ transplant recipients can affect the lungs or brain. Early lung infection treatment is crucial, as brain involvement significantly reduces survival rates.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Transplant Medicine

Background:

  • Ochroconis gallopava is a neurotropic mold causing respiratory and central nervous system (CNS) infections in poultry and immunocompromised individuals.
  • Three recent solid organ transplant (SOT) recipients with pulmonary Ochroconis infections were successfully treated.
  • This prompted a review of O. gallopava infections in SOT recipients.

Purpose of the Study:

  • To review published cases of Ochroconis gallopava infections in SOT recipients.
  • To analyze the impact of CNS infection on patient outcomes.

Main Methods:

  • Systematic literature review of O. gallopava infections in SOT recipients.
  • Analysis of clinical data, including site of infection and patient outcomes.
  • Statistical analysis to determine the impact of CNS involvement on survival.

Main Results:

  • A total of 12 cases (3 new, 9 published) were analyzed.
  • Pulmonary infection occurred in 42% of patients, CNS infection in 50%, and combined lung/skin in 1 patient.
  • Survival was significantly lower in patients with brain infection (33%) compared to those without (100%; P<0.03).

Conclusions:

  • Ochroconis gallopava exhibits a tropism for the CNS in SOT recipients.
  • Early recognition and treatment of pulmonary O. gallopava infections are vital.
  • Prognosis is excellent if infection is treated before CNS dissemination.

More Related Videos

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model10:31

Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model

Published on: August 13, 2017

Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...