Study on the TCM pathogenesis of angiopathic complications of type II diabetes

Excess production of reactive oxygen species (ROS) of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes. TCM holds that the damp from the dysfunction of spleen, kidney and liver is the causative factor of complications of diabetes. This is similar to the mechanism of ROS resulting in angiopathic complications of diabetes. When the angiopathic complications of type II diabetes mellitus (T2DM) are differentiated as caused by turbid damp in TCM can be explained as ROS. Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis, the treating principle should be dissolving the damp to remove the obstruction.