[Prelymphoma as a stage of malignant lymphoma (baboon malignant lymphoma model)]

Ten percent of the monkeys (more then 400 animals) from P. hamadrias herd of Sukhumi monkey colony died of a 20 year-long enzootic of malignant lymphoma associated with STLV-1 retrovirus. Retrospective analysis revealed regular (in more than 80% of cases) development of prelymphoma preceded by malignant process for a considerable time (up to 10 years or more). Prelymphoma occurred as mild hemopoietic inhibition including lymphopoiesis. Clinico-morphological signs of prelymphoma were: hypoplasia, edema and discomplexation in lymph nodes, anemia and inflammatory, i. e. degenerative lesions of the skin and mucous membranes.