Physiology and pathophysiology of the human spermatozoon: the role of electron microscopy

In this article, the major contributions of electron microscopy to the present understanding of the physiology and pathophysiology of the human spermatozoon are reviewed. The ultrastructural organization of sperm organelles playing a significant role for cell function and, therefore, for the reproductive process is described. Also, the major abnormalities and defects of the various organellar systems and how they impair the reproductive function and/or the viability of the cell are reviewed.