[Physiopathology of sarcoidosis]
1Inserm U700, Université Paris Diderot, Paris 7 UFR de médecine-site Bichat, 75870 Paris Cedex 18, France. paul.soler@inserm.fr
Abstract:
Sarcoidosis results from an uncontrolled cell-mediated immune reaction involving activated T cells and monocytes-macrophages, characterized by the formation of typical granulomas at the sites of the lesions. The interactions between both cell types induce the release of several mediators that play a central role in the development of granulomas, allowing to design new therapies. The aetiology of sarcoidosis remains unknown, but the disease is currently viewed as the consequence of a chronic immunological response associating a genetic susceptibility and specific environmental factors.
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