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Rapid Quantification of Oxidized and Reduced Forms of Glutathione Using Ortho -phthalaldehyde in Cultured Mammalian Cells In Vitro
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Rapid Quantification of Oxidized and Reduced Forms of Glutathione Using Ortho -phthalaldehyde in Cultured Mammalian Cells In Vitro

Published on: June 28, 2024

Pro-oxidant shift in glutathione redox state during aging

Igor Rebrin1, Rajindar S Sohal

  • 1Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90089, USA.

Advanced Drug Delivery Reviews
|July 26, 2008
PubMed
Summary

Aging impairs cellular redox balance by increasing oxidative stress and reducing glutathione (GSH) biosynthesis. The enzyme glutamate-cysteine ligase (GCL) shows reduced efficiency with age, potentially due to homocysteine accumulation, impacting lifespan.

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