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Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
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Postdates and antenatal testing.

Michael Y Divon1, Noa Feldman-Leidner

  • 1Department of Obstetrics and Gynecology, Lenox Hill Hospital, New York, NY 10075, USA. mdivon@lenoxhill.net

Seminars in Perinatology
|July 26, 2008
PubMed
Summary
This summary is machine-generated.

Prolonged pregnancies, defined as 42 weeks gestation, carry risks of adverse perinatal outcomes. This review examines fetal surveillance methods for managing these pregnancies, noting limitations in completely preventing stillbirths.

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Area of Science:

  • Obstetrics and Gynecology
  • Perinatal Medicine
  • Maternal-Fetal Medicine

Background:

  • Prolonged pregnancy is typically defined as 42 completed weeks of gestation.
  • Incidence varies, with an estimated 4-19% of pregnancies reaching or exceeding this threshold.
  • These pregnancies are associated with increased fetal and neonatal mortality and morbidity for both fetus and mother.

Purpose of the Study:

  • To review methodologies and protocols for fetal surveillance in prolonged pregnancies.
  • To evaluate the effectiveness and risks associated with fetal surveillance strategies.
  • To inform clinical practice regarding the management of post-term pregnancies.

Main Methods:

  • Review of existing literature and large computerized databases on well-dated pregnancies.
  • Analysis of studies investigating fetal surveillance techniques in prolonged gestation.
  • Examination of adverse perinatal outcomes and intervention risks.

Main Results:

  • Fetal surveillance aims to monitor prolonged pregnancies awaiting spontaneous labor.
  • False-positive surveillance tests can result in unnecessary, potentially harmful interventions.
  • Current fetal testing programs have not been proven to eliminate the risk of stillbirth entirely.

Conclusions:

  • Fetal surveillance is a key component in managing prolonged pregnancies.
  • Balancing the benefits of surveillance against the risks of intervention is crucial.
  • Further research is needed to optimize stillbirth prevention in post-term pregnancies.