Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cognitive Development During Adulthood

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...

Dementia

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.

Alzheimer Disease ll: Pathophysiology

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...

Alzheimer's Disease: Overview

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Dementia l: Introduction

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

COVID-19 Severity Index: A predictive score for hospitalized patients.

Medicina intensiva·2021

Same author

[Appearances are deceptive].

Der Radiologe·2021

Same author

COVID-19 Severity Index: A predictive score for hospitalized patients.

Medicina intensiva·2021

Same author

Trends in thyroid function testing, neck ultrasound, thyroid fine needle aspiration, and thyroidectomies in North-eastern Italy.

Journal of endocrinological investigation·2021

Same author

National survey of anatomical pathology centres in Italy: the questionnaire.

Pathologica·2019

Same author

Animal-based measures on fattening heavy pigs at the slaughterhouse and the association with animal welfare at the farm level: a preliminary study.

Animal : an international journal of animal bioscience·2019

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Published on: September 30, 2020

Cognitive and affective assessment and multiple pathologies in institutionalized elderly.

G Mazzoleni¹, D Fornaro, S Di Stefano

¹Institute of Internal Medicine and Geriatrics, Catania University, Cannizzaro Hospital, Via Messina 829, l-95126 Catania, Italy.

Archives of Gerontology and Geriatrics

|January 1, 1996

Summary

Cognitive deficits and depression increase with functional impairment in elderly patients. This study highlights the correlation between reduced function, cognitive decline, and mood disorders in older adults.

More Related Videos

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

Related Experiment Videos

Last Updated: Jul 3, 2026

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Published on: September 30, 2020

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

Area of Science:

Geriatric Medicine
Neuropsychology
Clinical Medicine

Background:

Elderly patients often experience cognitive decline and depression.
Multiple pathologies are common in older adults, potentially exacerbating these conditions.

Purpose of the Study:

To investigate the relationship between cognitive function, depression, and the number of pathologies in elderly patients.
To establish correlations using standardized assessments.

Main Methods:

Utilized the Mini-Mental State Examination (MMSE) and Geriatric Depression Scale (GDS) in 71 hospitalized elderly patients.
Classified patients into 5 grades based on functional impairment (British Columbia Classification).
Calculated mean scores for MMSE, GDS, and number of pathologies per functional grade.

Main Results:

Cognitive impairment (MMSE) and depression (GDS) prevalence increased with functional impairment grade.
All Grade IV patients exhibited cognitive impairment, and all Grade IV patients showed some degree of depression.
Patients with higher functional impairment grades (I-IV) showed a higher prevalence of cognitive deficits and depression compared to Grade 0.

Conclusions:

Functional impairment in elderly patients is strongly associated with increased cognitive deficits and depression.
Multidimensional evaluation is crucial for understanding the complex interplay of factors affecting elderly health.
Early identification and intervention for functional decline may mitigate cognitive and mood disorders in older populations.