Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Psychoneuroimmunology: Diabetes and Cancer

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...

Alzheimer Disease l: Introduction

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...

Type II Diabetes II: Pathophysiology

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.

Type I Diabetes II: Pathophysiology

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...

Diabetes: Symptoms, Diagnosis, and Complications

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Thermographic ocular temperature correlated with rectal temperature in cats.

Journal of thermal biology·2021

Same author

Clock gene per 2 daily rhythm: Correlation with the serum level of uncoupling protein 1 (UCP1) in goat and horse.

Journal of thermal biology·2021

Same author

Paget's disease of the male breast: case report and a point of view from actual literature.

Il Giornale di chirurgia·2018

Same author

Different training schedules influence platelet aggregation in show jumping horses.

Polish journal of veterinary sciences·2017

Same author

Leukocyte modifications during the first month after foaling in mares and their newborn foals.

Polish journal of veterinary sciences·2015

Same author

An efficient triazole-pyridine-bistetrazolate platform for highly luminescent lanthanide complexes.

Chemical communications (Cambridge, England)·2014

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

Diabetes and cognitive function: preliminary studies.

A Assisi¹, M Alimenti, F Maceli

¹Nutritional and Metabolic Unit, Italian National Research Centers on Aging, Via Cassia 1167, I-00189 Roma, Italy.

Archives of Gerontology and Geriatrics

|January 1, 1996

Summary

This study found no significant differences in cognitive function between older adults with well-controlled diabetes mellitus and those without. Further research may be needed to detect subtle cognitive deficits in diabetes.

More Related Videos

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

Related Experiment Videos

Last Updated: Jul 3, 2026

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

Area of Science:

Neuroscience
Endocrinology
Gerontology

Background:

Diabetes mellitus is a growing concern in aging populations.
Previous studies suggest a link between diabetes and cognitive decline.
The impact of well-controlled diabetes on cognition requires further investigation.

Purpose of the Study:

To investigate the relationship between diabetes mellitus and cognitive function in older adults.
To assess cognitive performance in patients with good metabolic control and no chronic complications.
To compare cognitive test results between diabetic and non-diabetic individuals.

Main Methods:

A cohort of 12 diabetic patients and 17 healthy controls, all over 50 years old, was studied.
Participants underwent a battery of cognitive tests including CES-D, Rey's, Benton's, Span's, Corsi's, MMSE, and Raven's.
Patients with diabetes maintained good metabolic control and had no chronic complications.

Main Results:

No statistically significant differences in cognitive function were observed between the diabetic and control groups.
This finding contrasts with some previous research on diabetes and cognition.
Potential reasons for discrepancies include differences in metabolic control or the sensitivity of cognitive tests used.

Conclusions:

Well-controlled diabetes mellitus without chronic complications may not significantly impair cognitive function in individuals over 50.
Subtle cognitive deficits in diabetes might exist but are not detectable by conventional neuropsychological tests.
Future studies should consider more sensitive measures or explore factors influencing cognitive outcomes in diabetes.