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Related Concept Videos

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Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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Gonadal and Placental Hormones

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Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model
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Published on: August 11, 2023

Hormone levels in centenarians.

M V Baldelli1, P Zucchi, J M Pradelli

  • 1Department of Internal Medicine, University of Modena, Viale Vittorio Veneto, 9, I-41100 Modena, Italy.

Archives of Gerontology and Geriatrics
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Hormone levels in centenarians are largely similar to younger adults, suggesting healthy aging preserves endocrine function. Key hormones like thyroid stimulating hormone (TSH) and growth hormone (GH) showed unremarkable changes in this centenarian study.

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Last Updated: Jul 3, 2026

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Published on: February 12, 2018

Area of Science:

  • Endocrinology
  • Gerontology
  • Human Physiology

Background:

  • Aging is associated with complex physiological changes, including alterations in hormone profiles.
  • Understanding the endocrine status of centenarians is crucial for insights into extreme longevity and healthy aging.

Purpose of the Study:

  • To investigate and compare serum hormone levels between centenarians and a younger elderly control group.
  • To identify potential age-related modifications or differences in the endocrine status of healthy centenarians.

Main Methods:

  • Serum concentrations of total triiodothyronine (T3), free thyroxine (fT4), TSH, cortisol, prolactin (HPRL), parathormone (PTH), osteocalcin, and growth hormone (GH) were measured.
  • Hormone levels in 12 centenarians were compared to those in 29 control subjects aged 67-98 years.

Main Results:

  • Serum levels of the studied hormones in centenarians were generally unremarkable.
  • Hormone levels in centenarians frequently fell within the normal range established for younger adult populations.
  • No significant age-related modifications were observed in the endocrine profiles of the centenarian group compared to controls.

Conclusions:

  • Healthy centenarians may maintain relatively stable endocrine profiles, similar to younger adults.
  • Extreme longevity in this cohort is not characterized by drastic hormonal deviations.
  • These findings suggest that hormonal homeostasis is well-preserved in healthy individuals reaching extreme old age.