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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and biological evaluation of C-12' substituted vinflunine derivatives
Xin Sheng Lei1, Xiang Da Yu, Long Yin
1Shanghai Hengrui Pharmaceuticals Co., Ltd., 279 Wenjing Road, Shanghai 200245, China.
Bioorganic & Medicinal Chemistry Letters
|July 26, 2008
Abstract:
A series of novel C-12' substituted vinflunine derivatives have been synthesized. Several compounds in this series possess comparable in vitro cytotoxic potency against A549 cell lines.

