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Risk factors of congenital hydrocephalus: a 10 year retrospective study
M Van Landingham1, T V Nguyen, A Roberts
1Department of Neurosurgery, University of Mississippi Medical Center, Jackson, MS 39216-4505, USA.
Insights
Identifying key risk factors for congenital hydrocephalus is crucial for early intervention. This study found that lack of prenatal care, maternal diabetes, hypertension, and alcohol use are significant risk factors in infants.
Area of Science:
- Pediatric Neurology
- Obstetrics and Gynecology
- Medical Genetics
Background:
- Congenital hydrocephalus is a complex neurological condition requiring identification of its underlying risk factors.
- Understanding the pathogenesis is essential for developing preventative strategies and improving infant outcomes.
Purpose of the Study:
- To identify and evaluate risk factors associated with the development of congenital hydrocephalus.
- To analyze a large patient population for statistically significant correlations.
Main Methods:
- Retrospective analysis of 596 congenital hydrocephalus cases from the University of Mississippi Medical Center (1998-2007).
- Data collection through ICD-9 database search and patient interviews covering maternal health, pregnancy, and family history.
Main Results:
- Significant risk factors identified include lack of prenatal care, multiparous gestation, maternal diabetes, chronic hypertension, gestational hypertension, and alcohol use.
- 12.1% of cases had a family history of hydrocephalus, suggesting a potential genetic component.
- Familial cases showed increased multiparous pregnancies and earlier prenatal care.
Conclusions:
- Several key risk factors are strongly linked to congenital hydrocephalus development.
- The prevalence of familial patterns indicates a significant role for genetic factors in the condition's pathogenesis.
Objective:
To evaluate and identify the risk factors associated with the pathogenesis of congenital hydrocephalus in a large specific population.
Methods:
An International Classification of Diseases (ICD)-9 database search of patients with congenital hydrocephalus treated at the University of Mississippi Medical Center between 1998 and 2007 was performed. All recruited patients were interviewed, assessing maternal age, onset of prenatal care, geographic location of pregnancy, maternal diabetes and chronic hypertension, pregnancy induced hypertension, pre-eclampsia, eclampsia, single or multiparous gestation, maternal alcohol, tobacco and drug use, infection and trauma during gestation, trauma or sexually transmitted disease at parturition, and other family members with hydrocephalus.
Results:
In this 10 year retrospective study, several significant risk factors were identified among 596 well defined cases of congenital hydrocephalus. The identified risk factors included lack of prenatal care, multiparous gestation, maternal diabetes, maternal chronic hypertension, maternal hypertension during gestation and alcohol use during pregnancy. Of these patients with congenital hydrocephalus, 12.1% identified an additional family member also diagnosed with hydrocephalus. No differences in risk factors were identified between sporadic and familial congenital hydrocephalus cases except for an increased incidence of multiparous pregnancies and prenatal care in the first trimester in familial cases.
Conclusions:
A number of key risk factors have been identified to be strongly associated with the development of congenital hydrocephalus in an infant. The prevalence of familial patterns of inheritance for congenital hydrocephalus suggests a broader role for genetic factors in the pathogenesis of congenital hydrocephalus.
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