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Related Experiment Video

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An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level

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Published on: November 2, 2020

Hypertrophic cardiomyopathy: lessons from history.

C J Coats¹, A Hollman

¹The Heart Hospital, 16-18 Westmoreland Street, London, UK. carolinecoats@doctors.org.uk

Heart (British Cardiac Society)

|July 26, 2008

Summary

Hypertrophic cardiomyopathy, a familial heart condition causing sudden death, was described by Robert Donald Teare 50 years ago. This review explores centuries of understanding this "tumour of the heart".

Area of Science:

Cardiology
Pathology
Medical History

Background:

Hypertrophic cardiomyopathy (HCM) has been recognized for centuries, with early descriptions focusing on thickened cardiac muscle.
Physicians and pathologists have long been intrigued by the condition of 'thick and heavy hearts'.

Observation:

Robert Donald Teare's seminal 1970s work in the British Heart Journal described HCM as a familial condition.
Teare characterized asymmetrical hypertrophy and myocyte disarray, likening HCM to a 'tumour of the heart'.

Findings:

Teare's observations highlighted the association of HCM with premature and sudden death in young individuals.
His work brought a poorly understood but recognized cardiac phenomenon into public and scientific discourse.

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Implications:

This review traces the historical progression of understanding hypertrophic cardiomyopathy.
It underscores the significance of Teare's contributions in advancing the diagnosis and study of HCM.