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Related Experiment Video

Updated: Jul 3, 2026

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

Published on: October 24, 2025

Variation in subfertility care measured by guideline-based performance indicators.

S M Mourad¹, W L D M Nelen, R P M G Hermens

¹Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

Human Reproduction (Oxford, England)

|July 26, 2008

Summary

This summary is machine-generated.

Subfertility care quality varies significantly across Dutch clinics. A new set of performance indicators reveals substantial gaps in adherence to guidelines, highlighting the need for improved fertility treatments and diagnostics.

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Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

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Published on: September 16, 2021

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Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

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Published on: October 24, 2025

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

Area of Science:

Reproductive Medicine
Healthcare Quality Improvement
Clinical Performance Measurement

Background:

Significant gaps exist between evidence-based guidelines and actual patient care in subfertility.
This can lead to suboptimal and costly diagnostic and treatment pathways for infertile couples.
Monitoring clinical practice is crucial for identifying and addressing these performance deficits.

Purpose of the Study:

To evaluate the quality of a previously developed set of 39 guideline-based performance indicators for subfertility care.
To utilize this indicator set to assess the current quality of subfertility care in Dutch clinics.

Main Methods:

A historic cohort study involving 16 Dutch subfertility clinics and 2698 couples.
Data collection through medical record extraction and patient/professional questionnaires.
Assessment of indicators based on criteria like measurability, reliability, applicability, and improvement potential.

Main Results:

1499 couples participated; all indicators were measurable, but other quality criteria varied.
14 out of 39 indicators showed less than 50% adherence.
Significant performance variation (up to 100%) observed between clinics.
Lowest adherence rates were in 'initial assessment of fertility' (43%) and 'anovulation' (44%) guidelines.

Conclusions:

The developed indicator set is suitable for monitoring clinical subfertility care quality.
The initial assessment in the Netherlands reveals considerable variation in care quality among clinics.
There is substantial opportunity to improve the quality of subfertility services and patient outcomes.