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Related Experiment Video

Updated: Jul 3, 2026

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
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Should SDMT substitute for PASAT in MSFC? A 5-year longitudinal study.

B Brochet1, M S A Deloire, M Bonnet

  • 1EA 2966, Université de Bordeaux, and Services de Neurologie et Neuroradiologie, CHU de Bordeaux, Bordeaux, France. bruno.brochet@chu-bordeaux.fr

Multiple Sclerosis (Houndmills, Basingstoke, England)
|July 26, 2008
PubMed
Summary

The Symbol Digit Modalities test (SDMT) may complement the Paced Auditory Serial Addition test (PASAT) in assessing multiple sclerosis (MS) cognitive function over time. SDMT showed better correlation with disability progression than PASAT.

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Area of Science:

  • Neuroscience
  • Clinical Neurology
  • Rehabilitation Medicine

Background:

  • The Multiple Sclerosis Functional Composite (MSFC) traditionally uses the Paced Auditory Serial Addition Test (PASAT) to assess cognition in patients with multiple sclerosis (MS).
  • Cognitive impairment is a significant challenge in MS, impacting daily functioning and quality of life.

Purpose of the Study:

  • To compare the performance of the MSFC incorporating the Symbol Digit Modalities Test (SDMT) against the standard MSFC using PASAT (MSFC [pasat]) in relapsing-remitting MS patients.
  • To evaluate the longitudinal correlation between these MSFC versions and clinical disability (Expanded Disability Status Scale - EDSS) and brain imaging parameters over five years.

Main Methods:

  • A cohort of 46 relapsing-remitting MS patients was followed for five years.

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  • The MSFC was assessed using both PASAT and SDMT at multiple time points.
  • Clinical disability was measured by EDSS, and brain magnetic resonance imaging (MRI) was performed at baseline.

    • Main Results:

    • While EDSS significantly worsened over five years, MSFC scores remained stable.
    • MSFC [sdmt] demonstrated a stronger correlation with EDSS over time compared to MSFC [pasat].
    • Baseline brain parenchymal fraction (BPF) correlated significantly with changes in both MSFC [sdmt] and MSFC [pasat] scores over the five-year period.

    Conclusions:

    • SDMT is a valuable complementary tool to PASAT for assessing cognitive function in MS, offering a potentially more sensitive measure of disease progression.
    • The study suggests incorporating SDMT into MSFC evaluations to enhance the comprehensive assessment of MS.
    • Cognitive assessment in MS should consider both traditional and newer measures to capture the multifaceted nature of the disease.