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Related Experiment Video

Updated: Jul 3, 2026

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli

Published on: January 13, 2013

Decrease of erythromycin resistance in group A streptococci by change of emm distribution.

Eun-Ha Koh¹, Sunjoo Kim, Nam Yong Lee

¹Department of Laboratory Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Korea.

Japanese Journal of Infectious Diseases

|July 26, 2008

Summary

This summary is machine-generated.

Group A Streptococcus (GAS) macrolide resistance in Korean children significantly decreased from 2002 to 2004. This decline in antibiotic resistance is linked to shifts in prevalent GAS emm types.

Related Experiment Videos

Last Updated: Jul 3, 2026

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli

Published on: January 13, 2013

Area of Science:

Microbiology
Infectious Diseases
Public Health

Background:

Increasing macrolide resistance in Group A Streptococcus (GAS) poses a public health concern.
Monitoring antibiotic resistance patterns in pediatric populations is crucial for effective treatment strategies.

Purpose of the Study:

To investigate the prevalence and antibiotic susceptibility of GAS in healthy elementary school children in Korea.
To compare macrolide resistance phenotypes, genotypes, and emm types of GAS isolates between 2002 and 2004.

Main Methods:

Throat cultures were performed on healthy elementary school children in 2004 to isolate GAS.
Antibiotic susceptibility testing was conducted for erythromycin and clindamycin.
Macrolide resistance mechanisms and emm genotyping were analyzed and compared with 2002 data.

Main Results:

Erythromycin and clindamycin resistance rates in GAS isolates decreased significantly from 51.0% and 33.7% in 2002 to 9.8% and 8.8% in 2004, respectively.
The prevalence of emm44/61 strains increased from 0% to 29.3%, while emm12 strains decreased from 34.4% to 6.4% between 2002 and 2004.
emm44/61 strains were uniformly susceptible to erythromycin, whereas 81.0% of emm12 strains exhibited erythromycin resistance.

Conclusions:

A significant reduction in GAS macrolide resistance was observed in Korean schoolchildren between 2002 and 2004.
The observed decrease in antibiotic resistance is strongly associated with a shift in the dominant emm types circulating in the community, with an increase in susceptible strains.
These findings highlight the dynamic nature of GAS epidemiology and the impact of emm type distribution on population-level antibiotic resistance.