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Updated: Jul 3, 2026

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers

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Published on: October 25, 2017

Nanotube-assisted protein deactivation.

Amit Joshi, Supriya Punyani, Shyam Sundhar Bale

Nature Nanotechnology

|July 26, 2008

Summary

Researchers demonstrate remote control of protein activity using carbon nanotubes. Near-infrared light selectively deactivates proteins in situ, enabling applications in pathogen destruction and self-cleaning coatings.

Area of Science:

Biomaterials Science
Nanotechnology
Photochemistry

Background:

Protein-carbon nanotube conjugates are valuable for biosensing, imaging, and cellular delivery.
Remote control of protein activity in these conjugates has remained a significant challenge.

Discussion:

Carbon nanotubes mediate selective protein deactivation in situ via photochemical effects upon near-infrared irradiation.
This method was used to design nanotube-peptide conjugates for targeted destruction of anthrax toxin.
Optically transparent, self-cleaning coatings were developed using this approach, functional after visible or near-infrared light exposure.

Key Insights:

Demonstrated remote, light-activated deactivation of proteins conjugated to carbon nanotubes.
Developed a novel method for selective protein destruction using photochemical effects.

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Created self-cleaning coatings with potential for broad applications.

Outlook:

Nanotube-assisted protein deactivation offers a versatile platform for pathogen and cell destruction.
Potential applications include antifouling coatings and advancements in functional proteomics.
This technology opens new avenues for controlled biological interactions at the nanoscale.