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Updated: Jul 3, 2026
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Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
Published on: May 12, 2019
[Nested-variant urothelial carcinoma. Case report and molecular aspects]
K Lindemann-Docter1, S V Koufou, E Dahl
1Universitätsklinikum Aachen, Pauwelsstrasse 30, 52074, Aachen. klindemann-docter@ukaachen.de
Der Pathologe
|July 26, 2008
Summary
Nested variant urothelial carcinoma is a rare bladder cancer. This case study reveals its de-novo genesis after Bacillus Calmette-Guérin treatment for non-invasive lesions.
Area of Science:
- Uro-oncology
- Pathology
- Molecular diagnostics
Background:
- Nested variant urothelial carcinoma (NVUC) is a rare, aggressive bladder cancer subtype.
- Characterized by bland morphology and early muscle invasion, posing diagnostic challenges.
- Non-invasive high-grade urothelial lesions require effective treatment strategies.
Observation:
- A 65-year-old male presented with non-invasive high-grade urothelial neoplasia (carcinoma in situ and pTa G3).
- Following Bacillus Calmette-Guérin (BCG) immunotherapy, the in situ component resolved.
- However, an invasive urothelial carcinoma, identified as nested variant, emerged.
Findings:
- Histopathological examination confirmed nested variant urothelial carcinoma in the bladder specimen.
- Molecular analyses suggested a de-novo origin for the invasive nested variant carcinoma.
- This indicates BCG treatment may have influenced the tumor's evolution.
Implications:
- The findings highlight the potential for de-novo genesis of nested variant urothelial carcinoma.
- This challenges current understanding of urothelial carcinoma progression after treatment.
- Further research is needed to elucidate the molecular mechanisms and clinical implications.
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