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Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage

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Published on: August 4, 2018

[Methods to evaluate cognitive disorders in animal models].

F Navarrete¹, J M Pérez-Ortiz, T Femenía

¹Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-CSIC, San Juan de Alicante, Alicante, España.

Revista De Neurologia

|July 26, 2008

Summary

This summary is machine-generated.

Animal models are crucial for studying cognitive dysfunction and dementia, offering insights into neurodegeneration and potential treatments. This review examines models and cognitive assessment tests for evaluating therapeutic interventions.

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Area of Science:

Neuroscience
Pharmacology
Gerontology

Context:

Aging populations in developed countries are experiencing increased rates of cognitive dysfunction and dementia.
Understanding the etiopathogenesis of cognitive deficits and neurodegeneration is a growing area of research interest.

Purpose:

To review existing animal models for human-related pathologies characterized by cognitive impairment and dementia.
To analyze the primary tests used to assess cognitive functions in experimental animals.

Summary:

This review focuses on animal models relevant to human cognitive disorders, particularly dementia.
It details methods for assessing cognitive function in these models.
The analysis includes how experimental treatments impact cognitive performance.

Impact:

Provides a framework for selecting appropriate animal models and cognitive tests in preclinical research.
Facilitates the evaluation of potential pharmacological targets for treating cognitive decline and neurodegenerative diseases.
Aims to guide the development of novel therapies for cognitive impairment and dementia.