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Related Concept Videos

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Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Related Experiment Video

Updated: Jul 3, 2026

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound
13:48

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound

Published on: April 21, 2023

The revascular active percutaneous interventional device for coronary total occlusions study.

Daniel Chamié1, Alexandre Abizaid, José Ribamar Costa

  • 1Interventional Cardiology Department, Instituto Dante Pazzanese de Cardiologia, São Paulo, Brasil.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|July 26, 2008
PubMed
Summary

The novel RVT CTO Guidewire Device (RVT-GDW) shows promise for crossing chronic total occlusions (CTOs) in coronary arteries. This first-in-man study found the device to be safe and effective, achieving a 62.5% procedural success rate.

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Last Updated: Jul 3, 2026

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound
13:48

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound

Published on: April 21, 2023

Area of Science:

  • Cardiovascular Interventions
  • Medical Device Technology

Background:

  • Percutaneous coronary intervention (PCI) for chronic total occlusions (CTOs) has limited success, often due to difficulty crossing lesions.
  • A novel guidewire system, the RVT CTO Guidewire Device (RVT-GDW), was developed to address these challenges.

Purpose of the Study:

  • To evaluate the efficacy and safety of the RVT-GDW for crossing complex CTO lesions.
  • To assess the feasibility of a new guidewire system in a first-in-man study.

Main Methods:

  • The RAPID-CTO study was a non-randomized, single-center, first-in-man trial.
  • The RVT-GDW features a mechanically active distal end, a torquer handle, and a control unit for enhanced crossing and positioning.
  • The device was used after conventional guidewires failed to cross the lesion for at least 5 minutes of fluoroscopy time.

Main Results:

  • 16 patients with CTOs were treated using the RVT-GDW.
  • Procedural success was achieved in 10 lesions (62.5%), with an average procedural time of 111.43 minutes.
  • No major adverse cardiac events were reported during in-hospital or 30-day follow-up.

Conclusions:

  • The RVT-GDW device is technically feasible, safe, and effective for crossing chronically occluded coronary arteries.
  • Further investigation in larger studies is warranted to confirm these findings.