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Updated: Jul 1, 2026

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
Published on: June 28, 2019
[Renal cell carcinoma presenting as paraneoplastic neurological dysfunction]
M J Hens1, B Camacho, A Maestre
1Servicio de Neurología, Complejo Hospitalario de Jaén. med000143@saludalia.com
Introduction:
Malignant tumors sometimes initiate as paraneoplastic syndromes even years before the most common symptoms appear. These first manifestations could be the key for the diagnosis of "occult" malignancy.
Methods:
We report the case of a 66 year old man with a renal cell carcinoma. The first symptom was a paraneoplastic cerebellar degeneration appeared 6 years before the first urologic manifestations.
Conclusions:
A progressive cerebellar syndrome could be the first manifestation of a renal cell carcinoma, even years before the first urologic symptoms. We must suspect an occult neoplasia in such patients.
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