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A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
07:07

A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice

Published on: May 10, 2013

[Prevalence of subnormal glomerular filtration rate in patients with diabetes mellitus]

I I Trofimenko, V A Dobronravov, N N Bystrova

    Terapevticheskii Arkhiv
    |July 29, 2008
    PubMed
    Abstract

    Insights

    Subnormal kidney function (GFR) is common in diabetes patients, even with normal or slightly increased albumin levels. Early screening for reduced GFR is crucial for managing diabetic kidney disease.

    Area of Science:

    • Nephrology
    • Endocrinology
    • Diabetology

    Background:

    • Diabetic kidney disease (DKD) is a major complication of diabetes mellitus (DM).
    • Assessing kidney function through glomerular filtration rate (GFR) and albuminuria is vital for DKD management.
    • Subnormal GFR prevalence in relation to albuminuria levels in diabetic patients requires further investigation.

    Purpose of the Study:

    • To determine the prevalence of subnormal glomerular filtration rate (GFR) in patients with diabetes mellitus (DM).
    • To evaluate the relationship between GFR and albuminuria levels in diabetic patients.
    • To assess the necessity of incorporating GFR estimation in routine diabetic patient care.

    Main Methods:

    • Estimated GFR using the MDRD formula in 851 diabetic patients (473 type 1 DM, 378 type 2 DM).
    • Measured urine protein and albumin excretion.
    • Categorized patients based on albuminuria status: normoalbuminuria (NAU), microalbuminuria (MAU), and proteinuria.

    Main Results:

    • Subnormal GFR (< 60 ml/min) was observed in 77% of type 1 DM and 40% of type 2 DM patients with NAU and MAU.
    • In type 1 DM, 8.3% with NAU and 16.4% with MAU had GFR < 60 ml/min.
    • In type 2 DM, 33% with normal serum creatinine had GFR < 60 ml/min.
    • A significant proportion of patients with proteinuria had advanced chronic kidney disease (stage III-V).

    Conclusions:

    • Subnormal GFR is prevalent in diabetic patients, including those with normoalbuminuria and microalbuminuria.
    • Routine GFR estimation should be implemented for screening, monitoring, and classifying renal damage in DM.
    • Albuminuria and proteinuria assessment alongside GFR is essential for comprehensive kidney disease evaluation in diabetics.

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