Related Experiment Video
Updated: Jul 3, 2026
07:29
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Two-year interval changes in Orbscan II topography in eyes with keratoconus
Afsun Sahin1, Nilgun Yildirim, Hikmet Basmak
1Eskisehir Osmangazi University Medical School, Department of Ophthalmology, Meselik, Eskisehir, Turkey.
Journal of Cataract and Refractive Surgery
|July 29, 2008
Summary
Orbscan II topography quantitatively documented keratoconus progression. Key findings include increased apex elevation, decreased corneal thickness, and steeper simulated keratometry, highlighting disease advancement over time.
Area of Science:
- Ophthalmology
- Corneal Imaging
- Biomedical Engineering
Background:
- Keratoconus is a progressive corneal ectasia characterized by thinning and steepening.
- Accurate topographic assessment is crucial for monitoring disease progression and guiding treatment.
Purpose of the Study:
- To quantitatively document changes in corneal topography parameters in keratoconus progression.
- To assess the utility of the Orbscan II topography system for serial analysis of keratoconic corneas.
Main Methods:
- Retrospective analysis of 79 eyes with keratoconus undergoing serial Orbscan II topography over approximately 24 months.
- Evaluation of topographic parameters including elevation, pachymetry, and curvature at the cornea's apex and thinnest point.
- Statistical analysis using paired t-tests to determine significant changes in parameters.
Main Results:
- Significant increases in apex elevation and displacement of the apex location were observed.
- Mean thinnest-point pachymetry decreased significantly, indicating corneal thinning.
- Mean simulated keratometry values increased significantly, indicating corneal steepening.
Conclusions:
- The Orbscan II topography system provides valuable quantitative data for tracking keratoconus progression.
- Serial topographic analysis using Orbscan II can effectively document changes in corneal shape and thickness over time.
Related Concept Videos
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...