Related Experiment Video
Updated: Jul 3, 2026

Analyzing Long-Term Electrocardiography Recordings to Detect Arrhythmias in Mice
Published on: May 23, 2021
Recorded heart sounds for identification of ventricular tachycardia
Richard Kobza1, Markus Roos, Stefan Toggweiler
1Division of Cardiology, Kantonsspital Luzern, Spitalstrasse, CH-6000 Luzern 16, Switzerland.
Background:
The ECG discrimination of ventricular tachycardia (VT) vs. supraventricular tachycardia (SVT) is both important and often difficult. In this study, we tested the hypothesis that recorded digital cardiac acoustical data reflect hemodynamic changes that can be used for VT detection.
Methods:
We studied 57 subjects (42 males, mean age 57, range 24-83 years) who had undergone electrophysiological testing for known and suspected cardiac arrhythmias. Acoustic cardiography (Audicor, Inovise Medical, Inc.) was performed during each subject's electrophysiological study. We evaluated the ability of S1 intensity and S1 variability to discriminate between VT and supraventricular rhythm.
Results:
The 57 subjects had 17 episodes of VT and 76 episodes of supraventricular rhythm--including 22 episodes of SVT. VT had a lower S1 intensity and higher S1 variability than supraventricular rhythm (2.63+/-1.78 mV vs. 4.70+/-5.03 mV and 0.45+/-0.24 vs. 0.21+/-0.11, respectively). Conversely, left bundle branch block, right bundle branch block or SVT did not affect either S1 intensity or its variability. Ventricular pacing increased S1 variability but did not affect S1 intensity. The sensitivity of S1 variability for detecting VT was 50% at 100% specificity.
Conclusion:
VT is associated with both decreased S1 intensity and increased beat-to-beat S1 variability. The electronic recording and digital processing of digital heart sound data is useful for identifying VT and may facilitate the differential diagnosis of clinically important tachyarrhythmias, particularly in emergency situations where advanced techniques such as electrophysiology studies are not available.
Related Concept Videos
Heart Sounds
Auscultation is the process of listening to these internal body sounds using a stethoscope. The heart produces four types of sounds, but only two—S1 and S2—can usually be heard with a stethoscope.
S1, also known as the "lub" sound, is caused by the closure of atrioventricular (A-V) valves at the...
Dysrhythmias III: Characteristics of Dysrhythmias
Dysrhythmias II: Classification of Tachyarrhythmias
Cardiovascular System Abnormal Findings II: Auscultation
Abnormal Heart Sounds
Gallops:
Assessment of the Cardiovascular System IV: Auscultation
Normal Heart Sounds
S1 (First Heart Sound)-
S1 is made by the closure of the mitral and tricuspid valves (atrioventricular valves), marking the beginning of systole.
S2 (Second Heart Sound)-
S2 is made by the closure of the aortic and pulmonic valves (semilunar valves), marking the end of the systole.
Electrocardiogram
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and the T...

