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Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
A synthetic method for peptide-PEG-lipid conjugates: application of octreotide-PEG-DSPE synthesis
Jian-Chiou Su1, Chin-Lu Tseng, Ting-Gung Chang
1Department of Medical Research, Kuang Tien General Hospital, 5-2, Datong Street, Shalu, Taichung 43353, Taiwan, ROC.
Abstract:
A solid phase synthesis method was established for the synthesis of peptide-poly(ethylene glycol)-lipid (peptide-PEG-lipid) conjugates. Octreotide-PEG(2000)-DSPE (OPD(2000)) was used as an example to demonstrate the synthetic approach. The OPD(2000) obtained had confirmed structure, activity, and purity providing a targeting molecule for preparation of well-defined drug delivery systems, such as targeted liposomes, for further studies.
