Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Vaccine Production

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

Modified-Release Drug Delivery Systems: Rate-Programmed II

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

Modified-Release Drug Delivery Systems: Rate-Programmed I

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...

Vaccinations

Vaccinations

Modified-Release Drug Delivery Systems: Overview

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Complement, coagulation and NET pathway activation underlies early host response to blowfly (Lucilia cuprina) infestation.

Parasites & vectors·2026

Same author

Characterising the innate immune response in breech strike resistant and non-selected sheep to the sheep blowfly (Lucilia cuprina).

Veterinary immunology and immunopathology·2025

Same author

The Immune Memory Response of In Vitro-Polarised Th1, Th2, and Th17 Cells in the Face of Ovalbumin-Transgenic <i>Leishmania major</i> in a Mouse Model.

International journal of molecular sciences·2024

Same author

Measuring the Manipulation of T Helper Immune Responses by <i>Schistosoma mansoni</i>.

International journal of molecular sciences·2022

Same author

The efficacy and safety of pinocembrin in a sheep model of bleomycin-induced pulmonary fibrosis.

PloS one·2021

Same author

Recognition of Schistosoma mansoni egg-expressed ovalbumin by T cell receptor transgenic mice.

Experimental parasitology·2019

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Published on: October 20, 2020

Virus-sized vaccine delivery systems.

Jean-Pierre Y Scheerlinck¹, Deanne L V Greenwood

¹Centre for Animal Biotechnology, Faculty of Veterinary Science, The University of Melbourne, Parkville, 3010 Vic., Australia. j.scheerlinck@unimelb.edu.au

Drug Discovery Today

|July 29, 2008

Summary

Virus-sized nanoparticles are a comeback in vaccine development, effectively inducing immune responses. This review explores various nanoparticle vaccine delivery systems and their immune induction mechanisms.

More Related Videos

Expression and Purification of Virus-like Particles for Vaccination

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

Published on: July 25, 2022

Related Experiment Videos

Last Updated: Jul 3, 2026

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Published on: October 20, 2020

Expression and Purification of Virus-like Particles for Vaccination

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

Published on: July 25, 2022

Area of Science:

Vaccinology
Nanotechnology
Immunology

Background:

Traditional vaccine development historically utilized viruses.
Modern advancements have led to the resurgence of virus-sized vaccine delivery systems.
Nanoparticles offer a promising platform for effective vaccine delivery.

Purpose of the Study:

To review nanoparticle-based vaccine delivery systems.
To discuss various strategies for generating these virus-sized particles.
To explore mechanisms of immune induction by these systems.

Main Methods:

Review of literature on nanoparticle vaccine delivery systems.
Discussion of strategies including virus-like particles, ISCOMs, and nanobeads.
Exploration of nanoparticle-based DNA vaccine delivery.

Main Results:

Nanoparticles in the virus size range are effective vaccine delivery systems.
Modern production technologies enhance their ability to induce immune responses.
Diverse methods exist for creating these nanoparticle systems.

Conclusions:

Virus-sized nanoparticles represent a powerful approach in modern vaccine development.
These systems effectively stimulate both cellular and humoral immunity.
Further research into immune induction mechanisms is warranted.