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Summary
An elevated erythrocyte sedimentation rate (ESR) prompted hospitalization and investigation in 59 patients. This led to diagnoses including tumors, inflammation, and hematologic disorders, though causes remained unknown in three cases.
Area of Science:
- Internal Medicine
- Hematology
- Oncology
Context:
- Elevated erythrocyte sedimentation rate (ESR) is a common indicator of inflammation.
- ESR is a non-specific marker requiring further investigation to determine the underlying cause.
- Hospitalization and detailed examination are sometimes necessary for patients with significantly elevated ESR.
Purpose:
- To investigate the spectrum of conditions associated with an accelerated erythrocyte sedimentation rate (ESR) in a cohort of hospitalized patients.
- To identify the diagnostic yield of close examination in patients presenting with elevated ESR.
Summary:
- Accelerated ESR in 59 patients led to hospitalization and comprehensive evaluation.
- Diagnoses included malignancies, soft tissue and vascular inflammation, and hematologic disorders characterized by M-gradient on protein electrophoresis.
- Disseminated atheromatosis was also identified as a potential underlying condition.
- In three cases (approximately 5%), the underlying cause for the elevated ESR could not be determined.
Impact:
- Highlights the importance of ESR as a critical diagnostic clue for serious underlying pathologies.
- Underscores the need for thorough investigation in patients with unexplained elevated ESR.
- Provides insights into the differential diagnosis for elevated ESR in a clinical setting.