Related Experiment Video
Updated: Jul 3, 2026
In Vivo Evaluation of the Mechanical and Viscoelastic Properties of the Rat Tongue
Published on: July 6, 2017
Morphologic and histologic outcomes of tongue reduction surgery in an animal model
Jonathan A Perkins1, Volodymyr Shcherbatyy, Zi-Jun Liu
1Division of Pediatric Otolaryngology, Children's Hospital and Regional Medical Center, Seattle, WA 98105-0371, USA. jonathan.perkins@seattlechildrens.org <jonathan.perkins@seattlechildrens.org>
Objective:
To describe the effect of anterior tongue reduction surgery on tongue size, morphology, and histology.
Design:
Prospective experiment.
Materials:
Twenty-two 12-week-old Yucatan minipigs.
Methods:
Six sibling pairs had tongue reduction (Group B) or sham surgery (Group A), and underwent euthanasia the day of surgery. Five sibling pairs had tongue reduction (Group D) or sham surgery (Group C), and were raised for four weeks. Data collected included changes in tongue morphology, histology, and animal response to surgery.
Results:
All animals tolerated surgery and maintained their weight. Tongue size was uniformly reduced in all animals as compared to sham surgery. Tongue reduction was stable long term in Group D. All animals had normal wound healing and neurovascular structure preservation. Fibrosis occurred at the repair site.
Conclusion:
Midline tongue reduction resulted in uniform tongue reduction in all dimensions and volume, without damaging neurovascular structures. Localized fibrosis is a sequela of healing.
